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• Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and suggestions for monitoring.
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac risk elements using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, probably secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the best coronary artery. Physicians and patients ought to concentrate on the scientific consequences of anabolic steroid abuse.

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Platform

Unfortunately, the data on using high dose anabolic steroids in humans are mainly supplied as case stories or small research that lack enough management teams. In addition, the data obtainable in the literature doesn’t account for the steroid kind or dose, as neither may be identified. Patients additionally could additionally be taking concomitant stimulants, similar to ephedra, which can confound information and the potential for adverse events. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 pure and artificial derivatives of testosterone, could cause a wide spectrum of medical sequalae.

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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses may even be beneficial in patients with angina , have larger ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood flow in males with established coronary artery illness .

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